Regenerative Endodontics: A Modern Approach to Healing Immature Teeth

A clear, evidence-based overview for dental professionals from the American Association of Endodontists’ Colleagues for Excellence newsletter.

What’s Inside

Regenerative endodontics has transformed how clinicians manage immature permanent teeth with pulpal necrosis—a condition traditionally associated with complex treatment pathways and a high risk of fracture. This issue of Colleagues for Excellence explores the biological foundations of regenerative endodontic procedures (REPs), evolving clinical protocols, and the latest research shaping this rapidly advancing field.

This eBook covers:

• A clear overview of regenerative endodontics, including how biologically based procedures emerged from revascularization research and tissue‑engineering principles.
• The foundational elements of regenerative therapy—stem cells, scaffolds, and growth factors—and how they work together to promote pulpal healing and continued root development.
• Current evidence‑supported clinical protocols for REPs, emphasizing case selection, minimally invasive disinfection, scaffold creation, and effective coronal sealing.
• Radiographic case examples that demonstrate resolution of periapical infection, increases in root length and thickness, and long‑term functional outcomes.
• Key factors influencing REP success and failure, including etiology, disinfection quality, and the survival of Hertwig’s epithelial root sheath.